Tropokine™ Carmen Marina 17 July 2025
Effectively Targets Inflammation and Pain Using Autologous Cytokine Therapy
Tropokine™

Tropokine™ is a next-generation autologous conditioned serum therapy, developed using the proven Tropocells® PRF platform. It is designed to control inflammation and support natural tissue regeneration—safely, effectively, and with biological precision.

Using a simple, single-spin preparation, Tropokine™ concentrates IL-1Ra (Interleukin-1 Receptor Antagonist)—a powerful, naturally occurring cytokine that blocks IL-1 signaling and promotes healing.

Tropokine™ mimics the therapeutic effect of steroids using only the body’s own healing proteins.
How It Works
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Inflammatory imbalance

Elevated levels of Interleukin-1 (IL-1) in damaged tissue bind to IL-1 receptors, triggering a cascade of inflammation, pain, and cartilage degradation.

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Targeted Tropokine™ therapy

Tropokine™ delivers a concentrated dose of IL-1Ra, which binds to IL-1 receptors and blocks inflammatory signalling.

Biological response
Biological response

IL-1Ra competitively blocks IL-1 receptors, restoring the inflammatory balance. Other autologous growth factors may also help protect cartilage and slow joint degeneration.

Setting New Standards
Why Tropokine™?
100% autologous

No additives or foreign substances

Built on Tropocells® PRF

Trusted platform with consistent results

Potent IL-1Ra concentration

Hyper-concentrated anti- inflammatory cytokine

Single-spin protocol

Efficient and easy-to-use process

Minimally invasive

Safe and well-tolerated injection-based therapy

No immunogenic risk

Biologically compatible with the patient’s body

Evidence-based Indications

Tropokine™ is suitable for a wide range of musculoskeletal and inflammatory conditions, supported by clinical and preclinical evidence.

  • Osteoarthritis (knee, hip, shoulder, ankle, etc.)
  • Tendinopathies (Achilles, patellar, rotator cuff)
  • Post-traumatic cartilage lesions
  • Discogenic pain and spinal osteoarthritis
  • Post-surgical inflammation (e.g., after arthroscopy or ACL repair)
  • Chronic synovitis and joint effusions
  • Muscle injuries and tendinitis
Simple and Standardized Preparation Protocol
Tropokine™ Preparation
1
Collect whole blood into the glass vacuum tube.

Collect whole blood into the glass vacuum tube.

2
Incubate at 37°C for 1–24 hours, depending on desired IL-1Ra concentration

Incubate at 37°C for 1–24 hours, depending on desired IL-1Ra concentration

3
Centrifuge at 1500g for 10 minutes

Centrifuge at 1500g for 10 minutes

 
4
Transfer IL-1Ra-rich serum to a 20 mL syringe using a disc filter.

Transfer IL-1Ra-rich serum to a 20 mL syringe using a disc filter.

5
Divide serum into aliquots for storage at –18°C

Divide serum into aliquots for storage at 
–18°C

6
Before use, thaw at room temperature and inject through a 0.22 μm filter

Before use, thaw at room temperature and inject through a 0.22 μm filter

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